CJC-1295 (No DAC) 10mg
CJC-1295 without Drug Affinity Complex (also known as modified GRF 1-29 or mod-GRF) is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH) with four amino acid substitutions that confer resistance to DPP-IV enzymatic degradation. Without the DAC (maleimidopropionic acid) conjugation that enables irreversible albumin binding, this form has a shorter half-life but produces more physiologic pulsatile GH release patterns, making it preferred for research protocols simulating natural GH secretion. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
CJC-1295 (no DAC) binds the GHRH receptor on anterior pituitary somatotrophs, activating Gs-adenylyl cyclase-cAMP-PKA signaling to stimulate GH synthesis and secretion. The four amino acid modifications (Ala at positions 2, 8, 15; Leu at position 27) prevent DPP-IV cleavage between His-Ala at position 1-2, extending activity from ~7 minutes (native GHRH) to ~30 minutes. Without DAC, it does not sustain albumin binding, producing acute GH pulses rather than sustained GH elevation.
Properties
Molecular Formula
C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight
3367.95 Da
Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Half-Life
~30 minutes (without DAC)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(2)Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
Ionescu M, Frohman LA.
Variability in anterior pituitary size within members of a GHRH receptor mutation kindred
Alba M, Fintini D, Salvatori R.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.