Source-first science
Purely PeptidesResearch
A structured peptide-science reference organized by compounds, molecular classes, mechanisms, and verified bibliography.
Taxonomy
Browse by compound class
Compound class
GLP-1 receptor peptide analogs
Designed peptide analogs whose declared molecular relationship is agonism at the glucagon-like peptide-1 receptor.
3 published compounds
Compound class
Multi-receptor incretin analogs
Single peptide molecules characterized against more than one receptor in the incretin and glucagon receptor families.
4 published compounds
Compound class
Kisspeptins
Peptides derived from the KISS1 precursor that share a C-terminal RF-amide motif and bind the kisspeptin receptor.
1 published compound
Compound class
Regenerative peptides
Synthetic peptides studied in connective-tissue and epithelial repair models, grouped by shared experimental context rather than by a common receptor.
1 published compound
Compound class
Copper-binding peptides
Peptides whose defining chemical feature is high-affinity coordination of Cu(II), forming discrete metal-peptide complexes with molecular identities distinct from the free peptide.
2 published compounds
Compound class
GHRH analogs
Synthetic analogs of growth hormone-releasing factor, typically modified fragments of the 44-residue human sequence, acting at the GHRH receptor.
3 published compounds
Compound class
Growth hormone secretagogues
Endogenous peptide ligands, synthetic peptides and nonpeptide mimetics acting at the growth hormone secretagogue receptor (the ghrelin receptor), a distinct receptor from the GHRH receptor targeted by GHRH analogs.
7 published compounds
Compound class
Mitochondrial-derived peptides
Peptides encoded by short open reading frames within the mitochondrial genome rather than the nuclear genome.
1 published compound
Compound class
Regulatory peptide fragment analogs
Short synthetic peptides constructed from a fragment of a larger endogenous regulatory peptide, commonly extended with a stabilizing C-terminal sequence.
3 published compounds
Compound class
Thymosin-related peptides
Peptides originally isolated from thymic tissue fractions, subsequently characterized as having functions unrelated to thymic hormone activity.
2 published compounds
Compound class
Melanocortin fragment peptides
Short peptides corresponding to fragments of melanocortin hormones, retaining part of the parent sequence while lacking the residues required for melanocortin receptor binding.
2 published compounds
Compound class
Nonpeptide receptor agonists
Small molecules characterized as agonists at receptors whose endogenous ligands are peptides, included here for comparison with the peptide agonists at the same receptor.
1 published compound
Compound class
Matrikine-derived peptides
Peptides corresponding to fragments of extracellular matrix proteins, typically studied for their reported effects on matrix synthesis in fibroblast culture.
5 published compounds
Compound class
Cyclic melanocortin analogs
Synthetic melanocortin receptor ligands closed into a macrocycle by a side-chain to side-chain bridge, in contrast to the linear fragment and full-length melanocortin peptides.
4 published compounds
Compound class
Amylin and calcitonin receptor agonists
Peptides that engage the calcitonin receptor and the amylin receptor complexes it forms with receptor activity-modifying proteins. Described as amylin analogs, they are not amylin-receptor-exclusive.
3 published compounds
Compound class
Linear melanocortin analogs
Full-length melanocortin peptide analogs that retain a linear backbone, distinguished from the cyclic lactam analogs and from the short melanocortin fragments.
1 published compound
Compound class
Neurotrophic peptide mimetics
Small synthetic peptides designed to mimic regions of neurotrophic factors, typically characterised through downstream pathway readouts rather than a demonstrated direct receptor target.
1 published compound
Compound class
Melanocortin receptor ligands
An umbrella for everything that acts at the melanocortin receptors regardless of chemistry — the native hormones, their fragments, cyclic analogs and nonpeptide small molecules. It exists so the native hormone is not filed as an analog of itself and a nonpeptide is not filed in a peptide class.
5 published compounds
Compound class
Incretin and glucagon receptor ligands
Endogenous hormones acting at the GLP-1, GIP and glucagon receptors, held together without any claim of common chemical ancestry. It exists so native hormones are not filed in a class of analogs of themselves.
5 published compounds
Entities
Compound directory
Canonical names, aliases, and scientific identifiers
Browse every published compound record without requiring client-side filtering.
Molecular index
Browse mechanisms
receptor
Glucagon-like peptide-1 receptor
GLP-1R is a class B G-protein-coupled receptor. The cited structural and pharmacology records characterize semaglutide and retatrutide as peptide agonists at this receptor.
11 linked published compounds
receptor
Glucose-dependent insulinotropic polypeptide receptor
GIPR is a class B G-protein-coupled receptor. The cited discovery and trial records identify it as one of the three receptor relationships declared for retatrutide.
3 linked published compounds
receptor
Glucagon receptor
GCGR is a class B G-protein-coupled receptor. Retatrutide's LY3437943 discovery record characterizes a molecular agonist relationship at GCGR alongside GIPR and GLP-1R.
5 linked published compounds
receptor
Kisspeptin receptor
KISS1R is a G-protein-coupled receptor historically reported as GPR54 and AXOR12. Foundational records identify KISS1-derived peptides as its endogenous ligands.
1 linked published compound
receptor
GHRH receptor
A class B G-protein-coupled receptor expressed on anterior pituitary somatotrophs. Synthetic growth hormone-releasing factor analogs are characterized by their activity at this receptor.
3 linked published compounds
binding-interaction
Cu(II) coordination
Formation of a discrete coordination complex between a peptide ligand and a Cu(II) ion. Spectroscopic study of the glycyl-L-histidyl-L-lysine complex reports a mononuclear 1:1 species at neutral pH with equatorial nitrogen coordination including the histidyl imidazole. Complex formation changes the molecular formula, mass, and analytical identity of the species relative to the free peptide, and is reversible by competing chelators.
1 linked published compound
signaling-pathway
Focal adhesion kinase signaling
A cytoskeletal signaling pathway in which focal adhesion kinase and paxillin phosphorylation coordinate cell adhesion, spreading, and migration.
1 linked published compound
receptor
Growth hormone secretagogue receptor
A G-protein-coupled receptor distinct from the GHRH receptor. Antagonist profiling reported that ipamorelin releases growth hormone through a GHRP-like receptor rather than through the GHRH receptor, establishing the two pathways as separate.
7 linked published compounds
signaling-pathway
AMPK signaling
A serine/threonine kinase complex that senses low cellular ATP and phosphorylates substrates that increase ATP generation and decrease ATP consumption. Reported as a central mediator of the cellular response to energetic stress and of multiple aspects of mitochondrial homeostasis.
1 linked published compound
binding-interaction
G-actin sequestration
Binding of monomeric globular actin by a peptide ligand, holding it in a form unavailable for filament assembly. Beta-thymosins are reported as the main intracellular G-actin-sequestering peptides in most vertebrate cells, with a dissociation constant in the micromolar range that permits rapid binding and release.
1 linked published compound
receptor
Innate repair receptor
A heteromeric receptor complex reported to comprise the erythropoietin receptor together with the beta common receptor (CD131), described as distinct from the EPOR homodimer that mediates erythroid maturation. Peptides characterized as selective agonists at this complex are reported not to engage the homodimeric receptor.
1 linked published compound
receptor
Melanocortin receptors
A family of five G protein-coupled receptors, MC1R through MC5R. ACTH recognition and signaling at MC2R depend on the accessory protein MRAP. Native hormones, peptide analogs and nonpeptide ligands differ in receptor-subtype recognition and functional direction; binding affinity, agonism and antagonism must be interpreted separately in the experimental system studied.
8 linked published compounds
receptor
Amylin and calcitonin receptors
The calcitonin receptor, and the amylin receptor complexes it forms when associated with receptor activity-modifying proteins RAMP1, RAMP2 or RAMP3. Because the amylin receptors are heteromers rather than distinct gene products, receptor construct and accessory-protein expression must accompany any selectivity claim; a potency ranking is not transferable between assay systems.
3 linked published compounds
receptor
CD36 scavenger receptor
A multifunctional scavenger receptor, distinct from the growth hormone secretagogue receptor, reported as a binding target for certain synthetic secretagogue peptides. It is recorded separately here precisely because collapsing it into the ghrelin-receptor mechanism would erase the finding that these compounds are not pharmacologically interchangeable.
2 linked published compounds
Reference paths
Chemistry and analytical science
Research Article
Peptide chemistry foundations
Begin with the site's existing primer, then use the glossary for precise molecular terminology.
Existing article URL preserved
Research Article
Analytical identity and purity
Continue to the existing HPLC and mass-spectrometry overview, with terminology linked through the glossary.
Existing article URL preserved
Freshness
Recently updated research
No post-publication updates have been recorded for the initial seed corpus. Publication and verification dates appear on every monograph.
Research map
Explore every research surface
Bibliography
Verified source records and durable identifiers.
Glossary
Anchored definitions for scientific terms.
Methodology
How identity and citation records are maintained.
Research Articles
Existing long-form articles at their original URLs.
Research Journal
The existing journal tool, kept distinct from Research.
Compounds
Canonical compound monographs and identifiers.
Compound Classes
Chemistry-first controlled taxonomy.
Mechanisms
Neutral receptor and molecular relationships.
52
Published compounds
131
Verified references
14
Published mechanisms