Cyclic melanocortin analogs

Compound

PT-141 (Bremelanotide)

PT-141, canonically bremelanotide, is a synthetic cyclic heptapeptide melanocortin receptor agonist, structurally the C-terminal free acid of the Melanotan II lactam scaffold.

Bremelanotide · PT 141 · PT-141 free base · PT-141

Compound

Melanotan II

Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone, closed by a lactam bridge between an aspartate and a lysine side chain.

Melanotan-II · MT-II · MT-2

Compound

Setmelanotide

Setmelanotide is a synthetic disulfide-cyclized octapeptide characterised as an MC4R-preferring melanocortin receptor agonist.

RM-493 · BIM-22493 · IRC-022493

Compound

SHU9119

SHU9119 is a cyclic lactam melanocortin analog whose receptor behaviour is subtype-dependent: antagonist at some melanocortin receptors and agonist at others.

SHU-9119 · SHU 9119

receptor

Melanocortin receptors

A family of five G protein-coupled receptors, MC1R through MC5R. ACTH recognition and signaling at MC2R depend on the accessory protein MRAP. Native hormones, peptide analogs and nonpeptide ligands differ in receptor-subtype recognition and functional direction; binding affinity, agonism and antagonism must be interpreted separately in the experimental system studied.