SLU-PP-332 (tablets) 20mg x 100 tablets
SLU-PP-332 is a small-molecule agonist of estrogen-related receptor (ERR) alpha, beta, and gamma — orphan nuclear receptors that regulate mitochondrial biogenesis, oxidative metabolism, and exercise adaptation gene programs. Developed at Saint Louis University, SLU-PP-332 has been described as an 'exercise mimetic' because it activates transcriptional programs normally induced by endurance exercise, including fatty acid oxidation, mitochondrial biogenesis, and muscle fiber-type switching, without physical activity. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
SLU-PP-332 binds to ERRα, ERRβ, and ERRγ, stabilizing the active conformation and promoting coactivator recruitment (PGC-1α, SRC family). This activates transcription of genes governing mitochondrial biogenesis (TFAM, NRF1/2), oxidative phosphorylation (cytochrome c, ATP synthase subunits), fatty acid β-oxidation (CPT1, ACADM, HADH), and slow-twitch muscle fiber programs (MYH7, troponin I slow). In murine models, SLU-PP-332 increased treadmill endurance by approximately 50% and enhanced resistance to muscle fatigue.
Properties
CAS Number
303760-60-3
Molecular Formula
C₁₈H₁₄N₂O₂
Molecular Weight
290.32 Da
Half-Life
~4-6 hours (estimated, preclinical)
Storage
Store at room temperature. Protect from moisture and light.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(2)Roles of ERRα in exercise physiology and metabolic regulation
Watt MJ, Southgate RJ, Holmes AG, Febbraio MA.
A pan-ERR agonist modulates the effects of exercise in mice
Kim SH, Kowalski S, Bhatt S, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.