SNAP-8 10mg
SNAP-8 (acetyl octapeptide-3) is a synthetic octapeptide that mimics the N-terminal domain of SNAP-25 (synaptosomal-associated protein of 25 kDa), one of the three SNARE complex proteins required for vesicular neurotransmitter release. It is an extension of the hexapeptide acetyl hexapeptide-3 (Argireline) with two additional amino acids, providing enhanced potency. SNAP-8 is primarily investigated in dermatological research as a topical neuropeptide for expression-line modulation. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
SNAP-8 competitively inhibits SNARE complex assembly by mimicking the SNAP-25 protein, thereby attenuating vesicular acetylcholine release at the neuromuscular junction of facial muscles. By reducing the efficiency of synaptic vesicle docking and fusion, SNAP-8 decreases the intensity of muscle contraction underlying expression lines. Unlike botulinum toxin (which cleaves SNARE proteins proteolytically and irreversibly), SNAP-8 acts as a reversible competitive antagonist.
Properties
CAS Number
868844-74-0
Molecular Formula
C₄₁H₇₀N₁₆O₁₆S
Molecular Weight
1075.16 Da
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
Half-Life
~4-6 hours (topical application dependent)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(1)A synthetic hexapeptide (Argireline) with antiwrinkle activity
Blanes-Mira C, Clemente J, Jodas G, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.