DSIP (Delta Sleep-Inducing Peptide)
10mg
Delta sleep-inducing peptide (DSIP) is a naturally occurring neuropeptide first isolated from the cerebral venous blood of rabbits during electrically induced sleep in 1977 by Schoenenberger and Monnier. This nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) crosses the blood-brain barrier and has been investigated for its role in modulating slow-wave sleep architecture, stress response, and neuroendocrine regulation. DSIP has also shown research interest in pain modulation and opioid withdrawal contexts.
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10% OFF · ends July 31Mechanism of Action
The precise receptor target of DSIP remains under investigation. Research suggests DSIP modulates GABAergic and glutamatergic neurotransmission, interacts with the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol and ACTH levels, and may influence circadian rhythm regulation through effects on melatonin and serotonin pathways. It has also been shown to modulate delta-wave EEG activity, the characteristic oscillation pattern of deep (stage N3) sleep.
Properties
Molecular Formula
C₃₅H₄₈N₁₀O₁₅
Molecular Weight
848.81 Da
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Half-Life
~7-8 minutes (rapid peripheral degradation)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(3)Characterization of a delta-electroencephalogram sleep-inducing peptide
Schoenenberger GA, Monnier M.
Delta sleep-inducing peptide: Structural analogs and their biological activity
Prudchenko IA, Starostina MV, Bhargava HN, et al.
Delta sleep-inducing peptide (DSIP): A still unresolved riddle
Kovalzon VM, Strekalova TV.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.