PE 22-28 10mg
PE 22-28 is a synthetic heptapeptide (Gly-Val-Ser-Trp-Gly-Leu-Arg) corresponding to residues 22-28 of the 44-amino-acid propeptide released during furin maturation of sortilin, also known as neurotensin receptor-3 (gene SORT1). It is the shortened active core of spadin (PE 12-28), a 17-residue fragment of the same propeptide, and was designed from the study of spadin's blood degradation products. The stated 773.89 Da is the free base; peptides of this class are commonly supplied as an acetate salt, for which the theoretical mono-acetate mass is 833.9 Da and the actual acetate content is lot-dependent. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
Select Option
2+ save 5% · 5+ save 10% · 10+ save 20%
- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
PE 22-28 is a selective blocker of TREK-1 (KCNK2), a two-pore-domain potassium channel whose inhibition is associated with antidepressant-like activity in rodent models. Reported in-vitro potency at human TREK-1 is sub-nanomolar - approximately 0.1 nM by whole-cell patch clamp on arachidonic-acid-activated channels, against 40-60 nM for spadin - with no comparable inhibition of TREK-2, TRAAK, TRESK, TASK-1 or the cardiac hERG channel at the concentrations tested. Duration of action for PE 22-28 itself is NOT established: the widely quoted figure of roughly 23 hours is a behavioural half-effect time measured in the forced swim test for chemically modified analogs (G/A-PE 22-28 and its biotinylated form), not a pharmacokinetic half-life and not a measurement of this peptide. Downstream endpoints studied in preclinical models include MAPK and PI3K pathway activation, hippocampal neurogenesis and synaptogenesis markers (PSD-95, synapsin), and BDNF expression. Some work reports a biphasic concentration-response at TREK-1, so dose selection is itself a research variable.
Properties
CAS Number
1801959-12-5
Molecular Formula
C₃₅H₅₅N₁₁O₉
Molecular Weight
773.89 Da
Sequence
Gly-Val-Ser-Trp-Gly-Leu-Arg
Half-Life
Not established - no published pharmacokinetic study
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(3)Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity
Djillani A, Pietri M, Moreno S, et al.
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design
Mazella J, Petrault O, Lucas G, et al.
Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Djillani A, Mazella J, Heurteaux C, Borsotto M.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.