Semax 10mg
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the N-terminal region of adrenocorticotropic hormone: it retains the ACTH(4-7) fragment Met-Glu-His-Phe and substitutes a Pro-Gly-Pro tripeptide for residues 8-10 (Arg-Trp-Gly), conferring enhanced metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax is classified as a nootropic and neuroprotective agent in Russian pharmacopoeia. It has been studied extensively in cognition and memory models, post-ischemic neuroprotection models, and for modulation of neurotrophic factor expression. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
Strength
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2+ save 5% · 5+ save 10% · 10+ save 20%
- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
Semax upregulates brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and TrkB receptor expression in hippocampal and cortical regions. It modulates the melanocortin system via MC4R interaction without significant adrenal steroidogenic activity in the studied dose ranges. Additional mechanisms include attenuation of nitric oxide synthase activity in ischemic tissue, modulation of serotonergic and dopaminergic neurotransmission, and enhancement of cholinergic signaling relevant to memory consolidation.
Properties
CAS Number
80714-61-0
Molecular Formula
C₃₇H₅₁N₉O₁₀S
Molecular Weight
813.93 Da
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Half-Life
~3-5 minutes (peripheral), extended CNS activity
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(3)[Nootropic and analgesic effects of Semax following different routes of administration]
Manchenko DM, Glazova NIu, Levitskaia NG, et al.
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al.
[Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke]
Miasoedova NF, Skvortsova VI, Nasonov EL, et al.
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Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.