Compound monograph
ARA-290
Cibinetide is a synthetic peptide corresponding to a surface region of erythropoietin, characterized in the literature as a selective agonist at a heteromeric receptor complex distinct from the erythropoietin receptor homodimer.
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Identity & nomenclature
Cibinetide is a synthetic peptide corresponding to a surface region of erythropoietin, characterized in the literature as a selective agonist at a heteromeric receptor complex distinct from the erythropoietin receptor homodimer.
Cibinetide is the INN. The development code PHBSP appears in the PubChem synonym set and abbreviates pyroglutamate helix B surface peptide; the related designation HBSP (helix B surface peptide) is used in the literature for the same structural concept. The peptide corresponds to a surface region of the erythropoietin molecule that is not involved in erythropoietin receptor homodimer binding.
Declared aliases and development codes: ARA 290, Cibinetida, Cibinetidum, PHBSP.
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Molecular properties
| Molecular formula | C51H84N16O21 |
|---|---|
| Molecular mass | 1257.3 Da |
| CAS Registry Number | 1208243-50-8 |
| PubChem CID | 91810664 |
| UNII | 9W5677JKDA |
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Structural characteristics
The source literature distinguishes two receptor arrangements: erythropoietin receptor homodimers, which mediate erythroid maturation, and heteromers of the erythropoietin receptor with the beta common receptor (CD131), termed the innate repair receptor. Cibinetide is described as a selective agonist at the latter that does not engage the homodimeric receptor, and therefore lacks the erythropoietic activity of erythropoietin itself.
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Molecular targets & mechanisms
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Analytical considerations
The molecular formula contains no sulfur, so sulfur-based oxidation pathways do not apply. Identity confirmation relies on mass and sequence-level methods.
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Verified bibliography
- Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.current
Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G
Scientific reports · 2017-10-12 · Journal Article
- Renoprotection and Mechanisms of Erythropoietin and Its Derivatives Helix B Surface Peptide in Kidney Injuries.current
Zhang Y, Chen W, Wu Y, Yang B
Current protein & peptide science · 2017 · Review
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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