Compound monograph
Epitalon
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, described in the source literature as a short peptide designed following work on pineal tissue extracts.
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Identity & nomenclature
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, described in the source literature as a short peptide designed following work on pineal tissue extracts.
Epitalon, Epithalon, and Epithalone all refer to the same tetrapeptide. A second registry number, 64082-79-7, also appears in the PubChem record; 307297-39-8 is carried here as primary. The literature describes the peptide as having been designed following work on a pineal extract preparation named Epithalamin, from which the name derives.
Declared aliases and development codes: Epithalon, Epithalone, AEDG peptide.
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Molecular properties
| Molecular formula | C14H22N4O9 |
|---|---|
| Molecular mass | 390.35 Da |
| CAS Registry Number | 307297-39-8 |
| PubChem CID | 219042 |
| UNII | O65P17785G |
| One-letter sequence | AEDG |
| Three-letter sequence | Ala–Glu–Asp–Gly |
Tetrapeptide Ala-Glu-Asp-Gly, stated identically in the PubChem synonym record and in the source literature.
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Structural characteristics
The sequence comprises four proteinogenic residues with no reported terminal modification in the PubChem record. Two of the four side chains are acidic, giving the peptide a low isoelectric point relative to neutral tetrapeptides.
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Molecular targets & mechanisms
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Analytical considerations
At 390 Da this is among the smallest peptides in the catalog, and it contains no aromatic residues, so UV detection at 280 nm gives no useful chromophore response. Identity confirmation relies on mass and sequence-level methods.
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Verified bibliography
- current
- Peptide Regulation of Cell Differentiation.current
Khavinson V, Linkova N, Diatlova A, Trofimova S
Stem cell reviews and reports · 2020-02 · Review
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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