Compound monograph
Liraglutide
Liraglutide is an acylated peptide analog of glucagon-like peptide-1, characterized against the GLP-1 receptor.
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Identity & nomenclature
Liraglutide is an acylated peptide analog of glucagon-like peptide-1, characterized against the GLP-1 receptor.
PubChem lists NN2211 as a development identifier for the liraglutide molecular record.
Declared aliases and development codes: NN2211.
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Molecular properties
| Molecular formula | C172H265N43O51 |
|---|---|
| Molecular mass | 3751 Da |
| CAS Registry Number | 204656-20-2 |
| PubChem CID | 16134956 |
| UNII | 839I73S42A |
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Structural characteristics
Built on the GLP-1(7-37) scaffold by a different strategy from semaglutide. Using native GLP-1 numbering, alanine 8 is retained, lysine 34 becomes arginine, and the lysine 26 side chain carries a C16 palmitoyl group through a single gamma-glutamyl spacer. Semaglutide's position-8 substitution and its longer diacid and spacer are not features of liraglutide. The related GLP-1(7-37) entry identifies the native structural parent. Receptor-dependence work using fluorescently labeled liraglutide reported binding within circumventricular organs and uptake into arcuate nucleus neurons expressing proopiomelanocortin and cocaine- and amphetamine-regulated transcript. Binding was not observed in GLP-1 receptor knockout mice, establishing that brain uptake in that model was receptor-dependent.
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Molecular targets & mechanisms
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Analytical considerations
Identity assessment must account for both the peptide backbone and the acyl modification represented in the PubChem molecular record, as for other acylated GLP-1 analogs in this library.
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Verified bibliography
- The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.current
Secher A, Jelsing J, Baquero AF, Hecksher-Sørensen J, Cowley MA, Dalbøge LS, Hansen G, Grove KL, Pyke C, Raun K, Schäffer L, Tang-Christensen M, Verma S, Witgen BM, Vrang N, Bjerre Knudsen L
The Journal of clinical investigation · 2014-09-09 · Journal Article
- Pharmacology, physiology, and mechanisms of incretin hormone action.current
Campbell JE, Drucker DJ
Cell metabolism · 2013-05-16 · Review
- Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.current
Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G
Nature · 2017-05-24 · Journal Article
- Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.current
Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW
Proceedings of the National Academy of Sciences of the United States of America · 2020-11-11 · Journal Article
- Structural basis for ligand recognition of incretin receptors.current
Underwood CR, Parthier C, Reedtz-Runge S
Vitamins and hormones · 2010 · Review
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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