Compound monograph
Selank
Selank is a synthetic heptapeptide consisting of the tetrapeptide tuftsin extended at the C-terminus with the tripeptide Pro-Gly-Pro.
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Identity & nomenclature
Selank is a synthetic heptapeptide consisting of the tetrapeptide tuftsin extended at the C-terminus with the tripeptide Pro-Gly-Pro.
Selank is the tetrapeptide tuftsin (Thr-Lys-Pro-Arg) extended at the C-terminus with Pro-Gly-Pro. The catalog separately lists N-acetyl selank amidate, a distinct molecule carrying an N-terminal acetyl group and a C-terminal amide. Registry numbers reported for that modified variant are inconsistent across suppliers and no CAS for it is published here.
Declared aliases and development codes: Selanc, Tuftsin-Pro-Gly-Pro.
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Molecular properties
| Molecular formula | C33H57N11O9 |
|---|---|
| Molecular mass | 751.9 Da |
| CAS Registry Number | 129954-34-3 |
| PubChem CID | 11765600 |
| UNII | TS9JR8EP1G |
| One-letter sequence | TKPRPGP |
| Three-letter sequence | Thr–Lys–Pro–Arg–Pro–Gly–Pro |
Sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, stated in the PubChem synonym record. The first four residues correspond to tuftsin.
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Structural characteristics
Selank follows the same fragment-plus-extension construction as Semax: a short sequence from a larger endogenous peptide, extended with a C-terminal Pro-Gly-Pro tripeptide. The sequence contains three proline residues, two of which are contributed by the extension.
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Molecular targets & mechanisms
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Analytical considerations
The sequence contains no aromatic residues and no sulfur, so UV detection at 280 nm gives no useful chromophore response and sulfur-based oxidation pathways do not apply. Because the catalog also carries an N-acetylated, C-amidated variant, identity methods must distinguish the two forms.
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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