Sermorelin

Sermorelin is the synthetic peptide corresponding to residues 1 to 29 of human growth hormone-releasing factor, the unmodified parent fragment from which several longer-acting analogs are derived.

Sermorelin corresponds to residues 1 to 29 of human growth hormone-releasing factor, the fragment commonly written GRF(1-29). Both CJC-1295 and tesamorelin, also in this library, are modified derivatives of this same fragment: CJC-1295 through a C-terminal maleimidopropionamide lysine substitution enabling albumin conjugation, and tesamorelin through a separate structural modification.

Declared aliases and development codes: GRF(1-29), Sermorelina, Sermorelinum.

Sermorelin is the unmodified GRF(1-29) fragment. The derivative work documented elsewhere in this library describes maleimido derivatives of hGRF(1-29) and their bioconjugation to human serum albumin, all three of which showed enhanced in vitro stability against dipeptidyl peptidase IV relative to the unmodified fragment. Sermorelin is therefore useful as the structural reference point against which those modifications are described.