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Research Catalog

Compound monograph

Tesamorelin

Tesamorelin is a synthetic analog of human growth hormone-releasing factor, characterized in the literature as a GRF analog acting at the GHRH receptor.

Published: 2026-09-04Literature/identifier verification: 2026-08-23
TH9507GHRH analogs

01

Identity & nomenclature

Tesamorelin is a synthetic analog of human growth hormone-releasing factor, characterized in the literature as a GRF analog acting at the GHRH receptor.

Development code TH9507 appears in the PubChem synonym set and in the contemporaneous literature. A second registry number, 804475-66-9, also appears in the PubChem record; 218949-48-5 is carried here as primary.

Declared aliases and development codes: TH9507.

02

Molecular properties

Molecular formulaC221H366N72O67S
Molecular mass5136 Da
CAS Registry Number218949-48-5
PubChem CID16137828
UNIIMQG94M5EEO

03

Structural characteristics

Tesamorelin is described in the literature as a synthetic growth hormone-releasing factor analog. The PubChem record includes a single sulfur atom, consistent with one sulfur-containing residue in the GRF-derived sequence.

04

Molecular targets & mechanisms

GHRH receptor

GHRHR · Growth hormone-releasing hormone receptor

A class B G-protein-coupled receptor expressed on anterior pituitary somatotrophs. Synthetic growth hormone-releasing factor analogs are characterized by their activity at this receptor.

05

Analytical considerations

Population pharmacokinetic analysis reports plasma clearance of approximately 1,060 L/h and a volume of distribution of approximately 200 L, characterized by a one-compartment model with first- and zero-order absorption and first-order elimination.

06

Verified bibliography

  1. Tesamorelin.

    Grunfeld C, Dritselis A, Kirkpatrick P

    Nature reviews. Drug discovery · 2011-02 · News

    current
    PMID 21283099DOI 10.1038/nrd3362TesamorelinGHRHR
  2. Tesamorelin, a human growth hormone releasing factor analogue.

    Wang Y, Tomlinson B

    Expert opinion on investigational drugs · 2009-03 · Review

    current
    PMID 19243281DOI 10.1517/13543780802707658TesamorelinGHRHR
  3. Drug evaluation: tesamorelin, a synthetic human growth hormone releasing factor.

    Tomlinson B

    Current opinion in investigational drugs (London, England : 2000) · 2006-10 · Review

    current
    PMID 17086939TesamorelinGHRHR
  4. Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects.

    González-Sales M, Barrière O, Tremblay PO, Nekka F, Mamputu JC, Boudreault S, Tanguay M

    Clinical pharmacokinetics · 2015-03 · Journal Article

    current
    PMID 25358450DOI 10.1007/s40262-014-0202-xTesamorelinGHRHR

10

Methodology & citation verification

Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.

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